woman suffering from an ocular migraine

CGRP plays a key role in migraine pathophysiology1

Migraine has a complex pathophysiology.1 However, research is revealing more about this neurological disease every day.1 Theories about migraine pathophysiology have evolved over time, and current research suggests that migraine involves both the central and peripheral neural and neurovascular systems.1

Although it is not firmly established where migraine initiates, it is clear that migraine involves activation of the trigeminal system.1 Additionally, recent findings reveal that the neuropeptide calcitonin gene-related peptide, or CGRP, is found in the trigeminal system and may be involved in the pathophysiology of migraine.1

CGRP has been implicated in a variety of migraine-related processes, such as1,2:


Understanding CGRP may help provide a more complete picture of the disease process, including insights that will advance the science of migraine.1

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CGRP = calcitonin gene-related peptide.


1. Russo AF. Calcitonin gene-related peptide (CGRP): a new target for migraine. Annu Rev Pharmacol Toxicol. 2015;55:533-552. 2. Goadsby PJ, Holland PR, Martins-Oliveira M, Hoffmann J, Schankin C, Akerman S. Pathophysiology of migraine: a disorder of sensory processing. Physiol Rev. 2017;97(2):553-622.